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Sequence of the functional human keratin K14 promoter.
Staggers, W R; Paterson, A J; Kudlow, J E.
Afiliación
  • Staggers WR; Department of Medicine, University of Alabama at Birmingham 35294.
Gene ; 153(2): 297-8, 1995 Feb 14.
Article en En | MEDLINE | ID: mdl-7533118
The K14 keratin is an intermediate filament produced in squamous epithelia. This tissue-specific expression is directed by the promoter (pK14) of the K14 gene which has been used extensively to direct the expression of transgenes to the skin. Human K14 was cloned and the upstream sequence is presented. In transient transfections, pK14 directs expression of a luciferase reporter in keratinocytes much more potently than in breast cancer cells.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Regiones Promotoras Genéticas / Queratinas Límite: Humans Idioma: En Revista: Gene Año: 1995 Tipo del documento: Article Pais de publicación: Países Bajos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Regiones Promotoras Genéticas / Queratinas Límite: Humans Idioma: En Revista: Gene Año: 1995 Tipo del documento: Article Pais de publicación: Países Bajos