Insulin induces tyrosine phosphorylation of a 90-kDa protein during postischemic brain reperfusion.

DeGracia, D J; O'Neil, B J; White, B C; Tiffany, B R; Krause, G S; Grossman, L I; Grunberger, G

DeGracia, D J; O'Neil, B J; White, B C; Tiffany, B R; Krause, G S; Grossman, L I; Grunberger, G.

Afiliación

DeGracia DJ; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201.

Exp Neurol ; 124(2): 351-6, 1993 Dec.

Article en En | MEDLINE | ID: mdl-7507063

RESUMEN

Rat brain nuclear proteins were examined for tyrosine phosphorylation after resuscitation from a 10-min cardiac arrest. Insulin (1 unit/kg intravenously), given immediately after resuscitation, caused a marked increase in tyrosine phosphorylation of a 90-kDa brain protein. This effect occurred without hypoglycemia and was not observed after insulin administration in previously insulinopenic, diabetic, nonischemic animals. Insulin-responsive tyrosine phosphorylation of a specific 90-kDa protein during reperfusion may represent insulin stimulation of a neuroprotective brain response to an ischemic insult, consistent with recent observations that insulin administration during reperfusion protects selectively vulnerable neurons from postischemic death.

Asunto(s)

Encéfalo/metabolismo; Paro Cardíaco/metabolismo; Insulina/farmacología; Ataque Isquémico Transitorio/metabolismo; Proteínas del Tejido Nervioso/metabolismo; Reperfusión; Análisis de Varianza; Animales; Encéfalo/efectos de los fármacos; Corteza Cerebral/efectos de los fármacos; Corteza Cerebral/metabolismo; Diabetes Mellitus Experimental/metabolismo; Paro Cardíaco/fisiopatología; Masculino; Reperfusión Miocárdica; Fosfoproteínas/aislamiento & purificación; Fosfoproteínas/metabolismo; Fosforilación; Fosfotirosina; Ratas; Ratas Wistar; Resucitación; Tirosina/análogos & derivados; Tirosina/análisis; Tirosina/metabolismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Reperfusión / Ataque Isquémico Transitorio / Paro Cardíaco / Insulina / Proteínas del Tejido Nervioso Límite: Animals Idioma: En Revista: Exp Neurol Año: 1993 Tipo del documento: Article Pais de publicación: Estados Unidos

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