Preferential usage of the T-cell receptor by influenza virus hemagglutinin-specific human CD4+ T lymphocytes: in vitro life span of clonotypic T cells.
J Virol
; 69(12): 8046-50, 1995 Dec.
Article
en En
| MEDLINE
| ID: mdl-7494319
Human helper T-cell (Th) responses to influenza A virus were studied by analyzing T-cell receptor V beta gene diversity in hemagglutinin-specific Th lymphocytes. The T-lymphocyte population from peripheral blood became quickly oligoclonal when stimulated in vitro with the HA306-329 peptide, and T-cell receptor V beta 3 genes were mainly expanded. Moreover, specific junctional region oligonucleotide probes corresponding to hemagglutinin-specific clones were used to estimate temporal diversity during antigenic stimulations.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
/
Linfocitos T CD4-Positivos
/
Linfocitos T Colaboradores-Inductores
/
Hemaglutininas Virales
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos