Propofol and isoflurane induced EEG burst suppression patterns in rabbits.
Acta Anaesthesiol Scand
; 39(6): 814-8, 1995 Aug.
Article
en En
| MEDLINE
| ID: mdl-7484040
The aim of this study was to compare propofol produced EEG burst suppression with isoflurane produced burst suppression in rabbits and to see whether rabbits can serve as models in studying the effects of different anaesthetics on human EEG. We recorded EEG of eight rabbits anaesthetised with isoflurane and propofol. The isoflurane bursts had higher amplitude than propofol bursts (P < 0.005). Isoflurane bursts appeared on distinct DC-shifts while propofol bursts were on slow waves. The EEG patterns were, however, different from those seen in humans. Rabbits did not have the rhythms seen in humans. We conclude that rabbits can be used to study the EEG effects of anaesthetics, such as the timing properties and reactivity of burst suppression pattern. However, this model seems less promising in the study of rhythmic activity seen in human EEG during burst suppression.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propofol
/
Anestésicos Intravenosos
/
Anestésicos por Inhalación
/
Electroencefalografía
/
Isoflurano
Límite:
Animals
Idioma:
En
Revista:
Acta Anaesthesiol Scand
Año:
1995
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Reino Unido