Acute effect of altered tryptophan levels and alcohol on aggression in normal human males.

Pihl, R O; Young, S N; Harden, P; Plotnick, S; Chamberlain, B; Ervin, F R

Pihl, R O; Young, S N; Harden, P; Plotnick, S; Chamberlain, B; Ervin, F R.

Afiliación

Pihl RO; Department of Psychology, McGill University, Montreal, Quebec, Canada.

Psychopharmacology (Berl) ; 119(4): 353-60, 1995 Jun.

Article en En | MEDLINE | ID: mdl-7480513

RESUMEN

Normal males received amino acid mixtures designed to raise or lower tryptophan availability, and thus to raise or lower brain serotonin synthesis. They also received alcoholic or non-alcoholic drinks. The subjects were tested in the Taylor Competitive Reaction Time Task in which they competed against a (non-existent) partner in a reaction time task. The magnitude of electric shocks that the subjects were willing to give to their bogus partner was used as a measure of aggression. Lowered tryptophan levels and ingestion of alcohol were associated with increased aggression. Our data support the idea that low serotonin levels may be involved in the etiology of aggression. They suggest that subjects with low brain serotonin levels may be particularly susceptible to alcohol-induced violence.

Asunto(s)

Agresión; Etanol/farmacología; Triptófano/farmacología; Adolescente; Adulto; Electrochoque; Humanos; Masculino; Tiempo de Reacción; Serotonina/metabolismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triptófano / Agresión / Etanol Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Humans / Male Idioma: En Revista: Psychopharmacology (Berl) Año: 1995 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Alemania

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