Determination of dextro- and levomethorphan mixtures using chiral lanthanide NMR shift reagents.
J Pharm Sci
; 69(4): 459-61, 1980 Apr.
Article
en En
| MEDLINE
| ID: mdl-7373546
Europium and praseodymium chiral NMR shift reagents were used to differentiate between dextro- and leveomethorphan. The enantiomeric shift differences (delta delta delta) demonstrated by the singlet associated with the methoxy protons were large enough to identify the levo- and dextro-isomers and to allow for the determination of as little as 10% of one enantiomer in the presence of the other in a prepared mixture. The analytical method is rapid and can analyze samples as small as 1 mg.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espectroscopía de Resonancia Magnética
/
Dextrometorfano
/
Levorfanol
Idioma:
En
Revista:
J Pharm Sci
Año:
1980
Tipo del documento:
Article
Pais de publicación:
Estados Unidos