A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds.
J Med Chem
; 24(10): 1230-6, 1981 Oct.
Article
en En
| MEDLINE
| ID: mdl-7328583
A series of new nontricyclic antidepressant compounds was synthesized. A representative of this class is compound 6. Five structural parameters were investigated: ring size, cis/trans stereochemistry, amide substitution, aromatic substitution, and amine substitution. The pharmacological tests employed, indicative of antidepressant activity, were yohimbine potentiation test, oxotremorine antagonism test, and apomorphine potentiation test. Structure--activity relationship is discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciclopentanos
/
Antidepresivos
Límite:
Animals
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1981
Tipo del documento:
Article
Pais de publicación:
Estados Unidos