[Clinical studies of the erythrocytosis produced by a new hemoglobin with oxygen affinity : Hb Hôtel-Dieu alpha 2A beta 2 Asp replaced by Gly (author's transl)]. / Polyglobulie par hémoglobine anormale hyperaffine pour l'oxygène : l'hémoglobine Hôtel-Dieu alpha 2 A beta 2 99 Asp replaced by Gly.
Ann Med Interne (Paris)
; 132(4): 225-8, 1981.
Article
en Fr
| MEDLINE
| ID: mdl-7305170
A new case of erythrocytosis associated with a high oxygen affinity hemoglobin is reported : the substitution of beta 99 of aspartic acid by glycine, characterized this abnormal hemoglobin, named "hemoglobin Hôtel-Dieu". An important associated smoking habit, probably responsible of an abnormal lung X-ray and of a disturbed CO transport, contributed to increase the difficulty of diagnosis. Familial inquiry, the search of an abnormal hemoglobin by standard or isoelectrofocusing electrophoresis, and the 2,3-DPG assay should be systematically performed in case of polycythemia in young people or in the absence of obvious aetiology. A corpuscular abnormality can be thus detected in about 10 p. cent of such polycythemias.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Policitemia
/
Hemoglobinas Anormales
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
Fr
Revista:
Ann Med Interne (Paris)
Año:
1981
Tipo del documento:
Article
Pais de publicación:
Francia