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Selective inhibition of human neutrophil chemotaxis by ECHO-virus, type 9.
Klin Wochenschr ; 59(11): 571-3, 1981 Jun 01.
Article en En | MEDLINE | ID: mdl-7265813
Preincubation (37 degrees C, 60 min) of human neutrophilic granulocytes with various concentrations of infectious ECHO virus, type 9, strain A. Barty resulted in virus-dose dependent inhibition of neutrophil chemotactic reactivity (Boyden-chamber assay) to chemoattractants (F-Met-Leu-Phen: zymosan-activated human serum). Other cellular functions-phagocytosis, increase of oxidative cell metabolism, intracellular killing of live staphylococci--remained intact. This selective inhibition of human neutrophilic chemotaxis was due to viral induced cytotoxicity or competitive inhibition of chemotactic cell surface receptors.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimiotaxis de Leucocito / Enterovirus Humano B / Echovirus 9 Límite: Animals Idioma: En Revista: Klin Wochenschr Año: 1981 Tipo del documento: Article Pais de publicación: Alemania
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimiotaxis de Leucocito / Enterovirus Humano B / Echovirus 9 Límite: Animals Idioma: En Revista: Klin Wochenschr Año: 1981 Tipo del documento: Article Pais de publicación: Alemania