[Comparison of the effects of absorption of aminophenazone or propyphenazone combined with sodium nitrite on the incidence and early appearance of tumors in the rat]. / Comparison des effets de l'absorption de l'aminophénazone ou de la propyphénazone associées au nitrite de sodium sur la fréquence et la précocité d'apparition de tumeurs chez le rat.
Ann Nutr Aliment
; 34(5-6): 1133-42, 1980.
Article
en Fr
| MEDLINE
| ID: mdl-7258913
Formation of nitrosamines, after absorption of nitrite and secondary or tertiary amines in the gastro-intestinal tract, is used as a chemical test of carcinogenicity in the Rat. We have confirmed the carcinogenic power of a tertiary amine association: aminophenazone, and sodium nitrite giving dimethyl-nitrosamine in Sprague Dawley rats: both substances are administered at low and high concentrations in drinking water. We have studied simultaneously, the propyphenazone/sodium nitrite association in the same experimental conditions without carcinogenic power: --treatment duration: thirty weeks, --study duration: two years with observation of carcinogenic reactions, --verification of data: control and substances given independently.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nitrito de Sodio
/
Carcinógenos
/
Aminopirina
/
Antipirina
/
Nitritos
Tipo de estudio:
Incidence_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
Fr
Revista:
Ann Nutr Aliment
Año:
1980
Tipo del documento:
Article
Pais de publicación:
Francia