The relationship between hormonal pregnancy tests and congenital anomalies: a prospective study.
Am J Epidemiol
; 113(5): 563-74, 1981 May.
Article
en En
| MEDLINE
| ID: mdl-7194580
ABSTRACT
PIP: Several retrospective and prospective studies have positively associated EPP (estrogen/progestogen preparations) with birth defects in the offsprings of exposed gravidas. Some 20,000 pregnancies of women in the Child Health and Development Studies (CHDS) in the San Francisco bay area between 1959 and 1966 were observed longitudinally. Congenital defects of children in the study (ascertained at birth and followed up in subsequent years) include structural aberrations and errors of metabolism. The CHDS study population includes 227 gravidas who were tested for pregnancy with EPP. 2 control groups consisted of those who were tested for pregnancy by either a serum or urine test. No statistically significant differences in the rates of severe congenital defects were observed between the hormonal test group and the 2 control groups (p 0.05). Relative risks and 95% confidence intervals were 1.01 (0.45-2.19) for the hormone/serum test comparison and 1.60 (0.60 to 4.18) for the hormone/urine test comparison. An insignificant increased risk for nonsevere genitourinary anomalies as observed in the male infants in the hormone group. Although this study did not confirm the hypothesized association between EPP and congenital anomalies in the CHDS population, the numbers in this series are not large enough to reject the hypothesis either. Further use of hormonal pregnancy tests appears unjustified in the light of the availability of non-risk pregnancy tests.
Palabras clave
Abortion, Induced; Biology; Congenital Abnormalities--etiology; Demographic Factors; Diseases; Endocrine System; Estrogens; Ethnic Groups; Examinations And Diagnoses; Fetal Death; Hormones; Laboratory Examinations And Diagnoses; Laboratory Procedures; Maternal Age; Mortality; Neonatal Diseases And Abnormalities; Parity; Physiology; Population; Population Dynamics; Pregnancy Tests; Progestational Hormones; Progesterone; Prospective Studies; Research Methodology; Studies; Urogenital Effects
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pruebas de Embarazo
/
Anomalías Inducidas por Medicamentos
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Epidemiol
Año:
1981
Tipo del documento:
Article
Pais de publicación:
Estados Unidos