Comparison of adjuvant postoperative radiotherapy and multiple-drug chemotherapy (CMF-VP) in operable breast cancer patients with more than four positive axillary lymph nodes.
Cancer
; 50(2): 212-8, 1982 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-7083128
With the advent of the adjuvant chemotherapy in 1974 for early operable breast cancer at Massachusetts General Hospital, 41 patients with greater than or equal to 4 lymph nodes positive in their axillary dissection received a two-year course of the modified Cooper regimen (S + CH) between March 1974 and June 1976. The actuarial disease-free survival was found to be comparable to CMF as reported by Bonnadonna. No consistent randomization with a control group was possible. Since postoperative radiotherapy has been proven to decrease the incidence of local recurrence but does not affect survival; it was believed that this group should serve as an adequate control. Sixty patients with greater than or equal to 4 positive axillary lymph nodes in their axillary dissection who were given postoperative radiotherapy to the chest wall and draining lymphatics (S + RT) in 1973 and 1974 at the same institution were retrospectively analyzed and compared to the above group. Relatively little significant difference in survival and disease-free survival curves was found. At 48 months, there was 72% and 58% survival for the S + RT and S + CH groups, respectively. When subgrouped according to age, those patients less than 49-years-old had a 48-month disease-free survival of 65% and 49% for S + RT and S + CH groups, respectively (P = 0.25). No significant difference was noted in the post menopausal group. In both groups, patients with greater than 50% positive axillary lymph nodes exhibited a poor prognosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Antineoplásicos
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
/
Middle aged
Idioma:
En
Revista:
Cancer
Año:
1982
Tipo del documento:
Article
Pais de publicación:
Estados Unidos