Group B streptococcal lung infection in neonatal rabbits.
Pediatr Res
; 16(3): 209-12, 1982 Mar.
Article
en En
| MEDLINE
| ID: mdl-7038607
The interaction of alveolar macrophages (AMs) and group B streptococci (GBS) was investigated in 1 and 2-day-old rabbits following infection in an exposure chamber containing 10(7) streptococci per cubic foot of air. The % of streptococci within AMs was similar at 0 and 4 h (36 and 65%) after infection for the two groups of rabbits. Twenty-four h after infection, the 2-day-old rabbits had a significantly higher % of ingested GBS (86 versus 68%). Sixty % of inspired GBS were inactivated by the older rabbits within 4 h after infection. This clearance persisted in the younger rabbits until 48 h (mean negative clearance of -17, -276, and -79% at 4, 24, and 48 h) before their numbers were reduced by inflammation. Sixty of 78 1-day-old rabbits had inflammatory responses between 24 and 72 h versus only 5 of 50 older rabbits. At 24 h after infection, AMs of 1-day-old rabbits contained significantly increased numbers of intracellular GBS microcolonies (17/20) than did AMs from 2-day-old rabbits (5/19). These observations suggest that the enhanced susceptibility to GBS infection in the immediate postnatal period is caused at least in part by ineffective intracellular killing by AMs.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neumonía
/
Infecciones Estreptocócicas
/
Streptococcus agalactiae
/
Macrófagos
/
Animales Recién Nacidos
Límite:
Animals
Idioma:
En
Revista:
Pediatr Res
Año:
1982
Tipo del documento:
Article
Pais de publicación:
Estados Unidos