T cell functional defect associated with thymid epithelial cell injury induced by a graft-versus-host reaction.
Transplantation
; 29(1): 61-6, 1980.
Article
en En
| MEDLINE
| ID: mdl-6989042
The injection of parental strain cells into adrenalectomized (CBA x A)F1 mice induced a graft-versus-host (GVH) reaction which was morphologically characterized by thymus epithelial cell injury but not stress-related thymic involution. Thymocytes from mice undergoing a GVH reaction were studied for their ability to reconstitute allograft reactivity in thymectomized, irradiated, bone marrow reconstituted (ATxBM) (CBA x A)F1 mice. Thymocytes of mice experiencing a GVH reaction were theta-positive during the course of the reaction, however, by 40 days after GVH induction these thymocytes were unable to reconstitute allograft reactivity to H-2-incompatible skin grafts. It is proposed that GVH-induced thymic epithelial cell injury prevents or arrests normal T cell differentiation, resulting in a population of thymocytes which lack complete functional capability.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Timo
/
Inmunología del Trasplante
/
Linfocitos T
/
Reacción Injerto-Huésped
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Transplantation
Año:
1980
Tipo del documento:
Article
Pais de publicación:
Estados Unidos