Effects of intracervical PGE2-gel on myometrial activity and cervical state in first trimester pregnancy.
Prostaglandins
; 24(3): 303-12, 1982 Sep.
Article
en En
| MEDLINE
| ID: mdl-6961477
ABSTRACT
PIP: In 7 primigravidae admitted for 1st trimester abortion by dilatation and evacuation, 0.5 mg prostaglandin E2 (PGE2) in a viscous gel (5 patients) or placebo gel (2 patients) was applied intracervically 6 hours prior to the operation. Throughout the treatment period, intrauterine pressure was recorded. Application of placebo gel induced no cervical ripening or myometrial activation. In all patients receiving active gel, a marked improvement of the cervical state was induced by the treatment. In 3 cases, this priming occurred parallel to minimal changes in myometrial activity without regular uterine contractions. In 2 patients, marked uterine activation was registered due to partial extraamniotic application. It is suggested that the PGE2 gel has a direct effect on cervical tissue. Furthermore, the risk of partially applying the gel in the extraamniotic space, thus stimulating the myometrium, depends on gel volume relative to the dimensions of the cervical canal and the application technique.
Palabras clave
Abortion, Induced; Age Factors; Biology; Cervical Effects; Cervix; Endocrine System; Family Planning; Fertility Control, Postconception; Genitalia; Genitalia, Female; Laboratory Procedures; Myometrial Effects; Myometrium; Physiology; Pregnancy; Pregnancy, First Trimester; Primiparity; Prostaglandins--administraction and dosage; Reproduction; Urogenital System; Uterus
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prostaglandinas E
/
Útero
/
Cuello del Útero
/
Aborto Terapéutico
/
Miometrio
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Prostaglandins
Año:
1982
Tipo del documento:
Article
Pais de publicación:
Estados Unidos