Effect of TMB-8 on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and the thromboxane mimic, U 46619.
Br J Pharmacol
; 77(1): 55-8, 1982 Sep.
Article
en En
| MEDLINE
| ID: mdl-6957253
1 TMB-8 (8-(N,N-diethylamino)octyl-3,4,5 trimethoxybenzoate HCl), an intracellular calcium antagonist, had no direct action on the pulmonary vasculature of the perfused canine lung lobe preparation. 2 The pulmonary pressor response to the thromboxane mimic, U46619, was not affected by TMB-8. 3 The vasopressor response to prostaglandin F2 alpha (PGF 2 alpha) was significantly attenuated but not completely blocked by TMB-8. 4 We conclude that the pulmonary pressor response to PGF 2 alpha is dependent on both intracellular and extracellular calcium pools for contraction and that U46619 facilitates either solely extracellular calcium influx or mobilizes an intracellular calcium pool not inhibited by TMB-8.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endoperóxidos de Prostaglandinas Sintéticos
/
Prostaglandinas F
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Vasoconstrictores
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Circulación Pulmonar
/
Ácido Gálico
Límite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Año:
1982
Tipo del documento:
Article
Pais de publicación:
Reino Unido