Familial pattern and transmission of Gilles de la Tourette syndrome and multiple tics.
Arch Gen Psychiatry
; 38(10): 1091-3, 1981 Oct.
Article
en En
| MEDLINE
| ID: mdl-6945827
Fifty-two patients with Gilles de la Tourette syndrome (TS) diagnosed according to DSM-lll criteria and/or their parents were interviewed regarding symptoms among family members. Occurrences of TS and multiple tics (MT) among first-degree relatives were distinguished to determine the familial patterns of the two diagnoses. comparing these data with family data collected on a random national sample of patients with TS, we found no differences between the two samples. Each separately and both combined showed that (1) MT seems to be a mild form of TS; (2) both MT and TS are transmitted in the same families; (3) the sex difference is real and not an artifact of ascertainment; and (4) the sex difference is related the the transmitted susceptibility as a threshold effect. A specific genetic mechanism has not been identified.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos de Tic
/
Síndrome de Tourette
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arch Gen Psychiatry
Año:
1981
Tipo del documento:
Article
Pais de publicación:
Estados Unidos