Serum and placenta levels of ethynylestradiol in presence of ethynodiol diacetate after oral administration.
Horm Res
; 16(4): 237-43, 1982.
Article
en En
| MEDLINE
| ID: mdl-6890038
ABSTRACT
PIP: The ethinyl estradiol concentration--in the presence of ethynodiol diacetate--in serum following oral administration was measured by a rapid radioimmunoassay method developed by the authors. It was found that the peak level was reached 1 hour after administration, and even after 12 hours, a significant amount of free ethinyl estradiol was present in the serum. The transfer of ethinyl estradiol into the placenta was also studied in subjects who were 10-12 weeks pregnant. Placenta serum quotients were calculated for the ethinyl estradiol, and were found to increase in parallel with the dose of the drug administered, proving that an ethinyl estradiol enrichment of the placenta occurred as early as 10-12 weeks of pregnancy.
Palabras clave
Contraception; Contraceptive Agents, Estrogen--analysis; Contraceptive Agents, Female; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents--administraction and dosage; Contraceptive Agents--analysis; Contraceptive Methods; Estradiol; Ethinyl Estradiol--analysis; Ethynodiol Diacetate--administraction and dosage; Family Planning; Laboratory Procedures; Oral Contraceptives; Oral Contraceptives, Combined; Reproductive Control Agents
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Placenta
/
Etinilestradiol
/
Diacetato de Etinodiol
Límite:
Pregnancy
Idioma:
En
Revista:
Horm Res
Año:
1982
Tipo del documento:
Article
Pais de publicación:
Suiza