[Effect of small amounts of 2,4-dichlorophenoxyacetic acid derivatives on thiamine and riboflavin metabolism in the animal body]. / Vliianie malykh kolichestv proizvodnykh 2,4-dikhlorfenoksiuksusnoi kisloty na obmen tiamina i riboflavina v zhivotnom organizme.
Vopr Pitan
; (2): 59-62, 1983.
Article
en Ru
| MEDLINE
| ID: mdl-6858074
Administration of the herbicide 2,4-DN (amine salt of 2,4-dichlorphenoxyacetic acid) to weanling rats in a dose of 1/20.000 and 1/2000 of the LD50 for 3 months brought about a 40-50% reduction of thiamine content in the organs and tissues of experimental animals as compared with control. The herbicide was introduced into a balanced formula diet. In the liver of rats given 2,4-DA, there was a 2-fold decrease in the content of flavine adeninedinucleotide, whereas the content of flavine mononucleotide showed a 2-fold rise. Besides, the rats given a lesser herbicide dose manifested a reduced excretion of riboflavine with urine, and an inhibition of liver succinate dehydrogenase. The same animals demonstrated an increase in the relative mass of the adrenals with a concurrent diminution in them of ascorbic acid content.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Riboflavina
/
Tiamina
/
Ácido 2,4-Diclorofenoxiacético
/
Dimetilaminas
Límite:
Animals
Idioma:
Ru
Revista:
Vopr Pitan
Año:
1983
Tipo del documento:
Article
Pais de publicación:
Rusia