UV-absorbing and other sun-protecting substances: genotoxicity of 2-ethylhexyl P-methoxycinnamate.

Bonin, A M; Arlauskas, A P; Angus, D S; Baker, R S; Gallagher, C H; Greenoak, G; Brown, M M; Meher-Homji, K M; Reeve, V

Bonin, A M; Arlauskas, A P; Angus, D S; Baker, R S; Gallagher, C H; Greenoak, G; Brown, M M; Meher-Homji, K M; Reeve, V.

Mutat Res ; 105(5): 303-8, 1982 Nov.

Article en En | MEDLINE | ID: mdl-6815524

RESUMEN

The mutagenicity of 2-ethylhexyl p-methoxycinnamate was demonstrated when 25 sunscreen ingredients were tested in the Salmonella/microsome assay. This substance also increased the frequency of sex-linked recessive lethals in Drosophila melanogaster. A trace contaminant may be implicated because many samples were obtained from several sources and the results were batch-related.

Asunto(s)

Cinamatos/farmacología; Mutágenos; Mutación; Protectores Solares/farmacología; Rayos Ultravioleta; Animales; Biotransformación; Drosophila melanogaster/genética; Genes Letales/efectos de los fármacos; Genes Recesivos/efectos de los fármacos; Microsomas Hepáticos/metabolismo; Pruebas de Mutagenicidad; Salmonella typhimurium/efectos de los fármacos; Relación Estructura-Actividad

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protectores Solares / Rayos Ultravioleta / Cinamatos / Mutágenos / Mutación Límite: Animals Idioma: En Revista: Mutat Res Año: 1982 Tipo del documento: Article Pais de publicación: Países Bajos

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