Identification of a chemoattractant for fibroblasts produced by human breast carcinoma cell lines.
Cancer Res
; 44(8): 3398-402, 1984 Aug.
Article
en En
| MEDLINE
| ID: mdl-6744273
Serum-free, conditioned media from the human breast tumor cell line ZR-75-1 and three other breast tumor cell lines were each found to contain a potent chemoattractant for fibroblasts. The chemoattractant activity was characterized and found to reside in a high-molecular-weight (Mr greater than 100,000) protein. This activity was stable to heating to 56 degrees and from pH 3 to 11, but it was sensitive to trypsin and pepsin treatment and to reduction. When crude attractant was placed in vivo in a slowly releasing pump, a fibrous tissue mass that formed at the releasing site within 11 days was 3- to 5-fold larger than was that observed with pumps containing control medium. It is likely that the production of a chemoattractant for fibroblasts by breast tumor cells might contribute to the fibrotic involvement that is common in breast carcinomas.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Factores Quimiotácticos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Cancer Res
Año:
1984
Tipo del documento:
Article
Pais de publicación:
Estados Unidos