Monocyte antibody-dependent cellular cytotoxicity in splenectomized subjects.
J Immunol
; 132(3): 1244-8, 1984 Mar.
Article
en En
| MEDLINE
| ID: mdl-6693766
Monocyte antibody-dependent cellular cytotoxicity (ADCC) was determined in normal subjects by using human A1 erythrocytes and immune human anti-A1 antiserum. The experimental data were fitted to a mathematical model and the values for maximal cytotoxicity and monocyte numbers required to produce 15% specific cytotoxicity (MD15) were subsequently computed and compared with the values for these two parameters estimated from the dose response curves. The values for both were significantly associated, and the mathematical model permitted precise quantitation of cytotoxicity in instances where this was impossible by standard methods. Maximal monocyte ADCC was significantly reduced in a group of splenectomized subjects, whereas the MD15 was increased. These findings emphasize the possible influences of the method of quantitation of ADCC and provide one explanation for the apparent conflict of published data.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esplenectomía
/
Monocitos
/
Citotoxicidad Celular Dependiente de Anticuerpos
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Immunol
Año:
1984
Tipo del documento:
Article
Pais de publicación:
Estados Unidos