Clinical evaluation in vivo and in vitro of cervical mucus in IUD users: differences between women wearing copper and progesterone releasing IUDs.
Acta Eur Fertil
; 14(4): 279-82, 1983.
Article
en En
| MEDLINE
| ID: mdl-6689512
ABSTRACT
PIP: Modifications of cervical mucus associated with IUD use were investigated in 5 women fitted with a copper IUD and 5 women with a progesterone-releasing device. Also investigated was the survival and viability of sperm in users of these 2 types of IUDs. Mucus was collected from study subjects before IUD insertion and 3 months after insertion; the quantity, spinnbarkheit, cellularity, and ferning capacity were assessed. A capillary tube test was also performed, and penetration depth, penetration density, motility duration, and migration reduction were evaluated. Women with a copper IUD in place showed no significant changes in cervical mucus measures after insertion. In contrast, insertion of the progesterone-releasing device significantly modified the spinnbarkheit and the cellularity of the mucus, with a dramatic increase of leukocyes. Similarly, although the copper IUD did not produce significant variations in penetration test parameters, insertion of the progesterone-releasing IUD was associated with a significant decrease in sperm concentrations penetrated at 1 cm, a marked drop in sperm motility and survival, and a significant decrease in the reduction of migration. These results indicate that progesterone-releasing IUDs produce important changes in cervical mucus and reduce sperm penetration and survival. It is hypothesized that the negative effect on the cervical mucus may be a principal mechanism of action of the progesterone-releasing contraceptive device.
Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progesterona
/
Moco del Cuello Uterino
/
Dispositivos Intrauterinos Medicados
/
Dispositivos Intrauterinos de Cobre
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Eur Fertil
Año:
1983
Tipo del documento:
Article
Pais de publicación:
Italia