Tissue distribution of thiopental and diazepam in rats at 71 atmospheres pressure.
Acta Anaesthesiol Scand
; 27(6): 433-8, 1983 Dec.
Article
en En
| MEDLINE
| ID: mdl-6666520
35S-thiopental 15 mg/kg and 14C-diazepam 5 mg/kg were injected intravenously in separate groups of rats (n = 6) at 1 ATA air and at 71 ATA air-He. Total radioactivity was measured in the brain, liver, kidney, muscle and fat after 1, 3, 5 and 15 min. The thiopental content was significantly reduced at pressure in the brain at 3, 5 and 15 min. The diazepam content of the brain was significantly reduced at pressure at 1, 5 and 15 min. The liver, muscle and kidney tissue generally contained slightly less of either drug at pressure, particularly at the earliest sampling times.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Presión Atmosférica
/
Tiopental
/
Diazepam
Límite:
Animals
Idioma:
En
Revista:
Acta Anaesthesiol Scand
Año:
1983
Tipo del documento:
Article
Pais de publicación:
Reino Unido