Synergistic effect of hypoglycemic sulfonylureas and negative phospholipids on calcium transport: ionic and conformational aspects.
Res Commun Chem Pathol Pharmacol
; 41(3): 407-24, 1983 Sep.
Article
en En
| MEDLINE
| ID: mdl-6635329
In a two-phase bulk system for the study of ionophoresis, the capacity of hypoglycemic sulfonylureas to translocate Ca2+ was enhanced in a synergistic manner by negatively charged phospholipids. High concentrations of Na+ or K+ had relatively little effect on sulfonylurea-mediated Ca2+ translocation. The acidity constant of hypoglycemic sulfonylureas ranged from 10(-5) to 10(-6). The conformation analysis of Ca2+ -gliquidone complexes with a 1:1 or 1:2 stoichiometry and of a hybrid complex between Ca2+ and both gliquidone and phosphatidylserine revealed configurations suitable for Ca2+ transport across a hydrophobic domain. These findings raise the possibility that the cationic response of the pancreatic B-cell to hypoglycemic sulfonylureas may be due primarily to an alteration of both Ca2+ and H+ transport.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfolípidos
/
Compuestos de Sulfonilurea
/
Calcio
/
Hipoglucemiantes
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Res Commun Chem Pathol Pharmacol
Año:
1983
Tipo del documento:
Article
Pais de publicación:
Estados Unidos