Liposomal methotrexate in the treatment of murine L1210 leukemia.
Cancer Drug Deliv
; 1(1): 59-62, 1983.
Article
en En
| MEDLINE
| ID: mdl-6544118
To assess the therapeutic effectiveness of methotrexate (MTX) when administered in a liposome carrier, mice bearing intracranial L1210 leukemia were tested with liposomal MTX, free MTX, or saline. Single i.p. injections of liposomal MTX at doses of 5 mg/kg and 2.5 mg/kg prolonged survival of mice bearing intracranial L1210 leukemia. The same doses of the free drug did not prolong survival of the tumor-bearing mice. This system may have clinical application not only for MTX, but also other polar anticancer agents in the treatment for central nervous system malignancy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia L1210
/
Metotrexato
/
Liposomas
Límite:
Animals
Idioma:
En
Revista:
Cancer Drug Deliv
Asunto de la revista:
ANTINEOPLASICOS
/
TERAPIA POR MEDICAMENTOS
Año:
1983
Tipo del documento:
Article
Pais de publicación:
Estados Unidos