A comparison of thermospray and direct liquid introduction high-performance liquid chromatography/mass spectrometry for the analysis of candidate antimalarials.
Biomed Mass Spectrom
; 11(12): 616-21, 1984 Dec.
Article
en En
| MEDLINE
| ID: mdl-6529592
The analysis of antimalarials by high-performance liquid chromatography (HPLC)/mass spectrometry demonstrates a new dimension in specificity along with increased sensitivity compared to conventional HPLC detection methods. Both direct liquid introduction and thermospray HPLC/mass spectrometry interfaces provided molecular weight information as well as characteristic fragment ions for antimalarials not normally amenable to direct probe or gas chromatographic/mass spectrometric techniques. The direct liquid introduction interface, which incorporated a 1/100 split, showed a detection limit of 30 ng using selected ion monitoring. The thermospray technique showed less than 1 ng detection limits using selected ion monitoring.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espectrometría de Masas
/
Cromatografía Líquida de Alta Presión
/
Antimaláricos
Límite:
Animals
Idioma:
En
Revista:
Biomed Mass Spectrom
Año:
1984
Tipo del documento:
Article
Pais de publicación:
Reino Unido