[Ascorbic acid supply and cytochrome P-450 levels in guinea pig liver after dimethylformamide poisoning]. / Obespechennost' askorbinovoi kislotoi i uroven' tsitokhroma P-450 v pecheni morskikh svinok pri intoksikatsii dimetilformamidom.
Vopr Pitan
; (5): 65-7, 1984.
Article
en Ru
| MEDLINE
| ID: mdl-6516287
The universal solvent dimethylformamide (DMFA) administered to guinea-pigs in a dose of 400 mg/kg bw per os for 14 days produced a considerable decrease in the content of total and reduced ascorbic acid (AA) in the liver, in all forms of AA in the adrenals, and lowering of vitamin C excretion with daily urine. The liver showed an increase in the concentration of dehydroascorbic acid and diminution of the concentration of cytochrome P-450 detected in liver homogenates. Additional administration of AA (50 mg/day) recovered the lowered level of the vitamin in the liver and adrenals but did not make the daily excretion of AA with urine return to normal. Additional administration of vitamin C to guinea-pigs recovered the level of cytochrome P-450 in liver homogenates, which was reduced during DMFA poisoning. One of the reasons for the development of vitamin C deficiency during DMFA poisoning is likely to be high oxidation of AA.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Ascórbico
/
Sistema Enzimático del Citocromo P-450
/
Dimetilformamida
/
Hígado
Límite:
Animals
Idioma:
Ru
Revista:
Vopr Pitan
Año:
1984
Tipo del documento:
Article
Pais de publicación:
Rusia