Microinjection of neostigmine into the pontine reticular formation of cats enhances desynchronized sleep signs.
J Pharmacol Exp Ther
; 231(1): 173-80, 1984 Oct.
Article
en En
| MEDLINE
| ID: mdl-6491973
Microinjection of the acetylcholinesterase inhibitor neostigmine into the dorsal pontine tegmentum of intact, freely moving cats produced significant changes in electrographic desynchronized (D) sleep signs and D sleep-like behavior. The percentage, frequency and duration of D sleep signs were increased and the latency to onset of D sleep signs was significantly reduced after neostigmine administration. The effects of neostigmine were dose-dependent and could be blocked by centrally administered atropine. This is the first demonstration that microinjection of an acetylcholinesterase inhibitor into the pons enhances D sleep signs. These data suggest that endogenously released acetylcholine can initiate and maintain the state of D sleep and strongly support the cholinergic hypothesis of D sleep generation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Formación Reticular
/
Sueño
/
Puente
/
Neostigmina
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Pharmacol Exp Ther
Año:
1984
Tipo del documento:
Article
Pais de publicación:
Estados Unidos