Efficacy of mebendazole and albendazole against Trichinella spiralis in mice.
J Parasitol
; 64(2): 214-9, 1978 Apr.
Article
en En
| MEDLINE
| ID: mdl-641662
Changes in the sensitivity of Trichinella spiralis to anthelmintic treatment during the first 3 days of infection in mice were studied. Oral administration of either mebendazole or albendazole at 6.25 mh/kg 2 hr after exposure to infection eliminated 95-100% of the worms as determined at necropsy on day 7 postinoculation. Beyond the first day of infection the sensitivity of the parasite to benzimidazole therapy was much reduced and an oral dose of 50 mg/kg was only partially but significantly active against the adult worms. Despite decline in drug sensitivity during the enteral phase, gavage administration of either mebendazole or albendazole at 50 mg/kg for 5 consecutive days during the invasive phase of infection significantly reduced (96 and 67%, respectively) the number of larvae subsequently recovered from host musculature on day 45 postinoculation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triquinelosis
/
Bencimidazoles
/
Mebendazol
Límite:
Animals
Idioma:
En
Revista:
J Parasitol
Año:
1978
Tipo del documento:
Article
Pais de publicación:
Estados Unidos