Complete hydatidiform moles combine maternal mitochondria with a paternal nuclear genome.

Edwards, Y H; Jeremiah, S J; McMillan, S L; Povey, S; Fisher, R A; Lawler, S D

Edwards, Y H; Jeremiah, S J; McMillan, S L; Povey, S; Fisher, R A; Lawler, S D.

Ann Hum Genet ; 48(2): 119-27, 1984 05.

Article en En | MEDLINE | ID: mdl-6331273

RESUMEN

The parental origin of mitochondria in hydatidiform moles has been investigated by analysis of genetic variants of mtDNA restriction enzyme patterns. In six complete moles the mtDNA was found to be maternal in origin, with no contribution from the sperm mitochondria, while the nuclear genome was shown to be exclusively paternal in five cases. The occurrence of mtDNA variation in the healthy population was investigated using white blood cells and placentae, and the most common variation occurred at the Ava II restriction sites. The variants exhibited by molar mtDNA were the same as those found in material from healthy individuals.

Asunto(s)

ADN Mitocondrial/genética; Mola Hidatiforme/genética; Neoplasias Uterinas/genética; Enzimas de Restricción del ADN; ADN de Neoplasias/genética; Femenino; Variación Genética; Heterocigoto; Homocigoto; Humanos; Mola Hidatiforme/análisis; Leucocitos/análisis; Mitocondrias/análisis; Linaje; Placenta/análisis; Embarazo; Neoplasias Uterinas/análisis

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Uterinas / ADN Mitocondrial / Mola Hidatiforme Límite: Female / Humans / Pregnancy Idioma: En Revista: Ann Hum Genet Año: 1984 Tipo del documento: Article Pais de publicación: Reino Unido

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