Monoamine metabolites in the CSF of conscious unrestrained cats.
Brain Res
; 277(2): 283-7, 1983 Oct 31.
Article
en En
| MEDLINE
| ID: mdl-6196083
The dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) were measured repeatedly over a period of up to 5 months at different sites of the brain ventricular system in unrestrained, awake cats. Samples of 10 microliter CSF were analyzed by high pressure liquid chromatography and subsequent electrochemical detection. Concentrations were in the range of 30-130 ng/ml for DOPAC, 110-340 ng/ml for 5-HIAA and 180-750 ng/ml for HVA. The monoamine metabolites were constant even over a period of several months if measured in the same animal but there was a marked interindividual variation. A marked gradient for monoamine metabolites was found when CSF samples from frontal sites of the lateral ventricle were compared to CSF samples from the dorsal lateral ventricle. The concentrations of DOPAC and HVA were higher at frontal sites.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenilacetatos
/
Encéfalo
/
Ácido 3,4-Dihidroxifenilacético
/
Ácido Homovanílico
/
Ácido Hidroxiindolacético
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1983
Tipo del documento:
Article
Pais de publicación:
Países Bajos