Nerve growth factor increases substance P, cholecystokinin and vasoactive intestinal polypeptide immunoreactivities in primary sensory neurones of newborn rats.
Neurosci Lett
; 34(2): 153-8, 1982 Dec 30.
Article
en En
| MEDLINE
| ID: mdl-6191253
Immunoreactive substance P, somatostatin, gastrin/cholecystokinin and vasoactive intestinal polypeptide were studied in lumbar dorsal root ganglia of 14-day-old rats treated from day 2 to 11 of life with nerve growth factor. Increased staining intensity of neuronal cell bodies and processes for substance P, gastrin/cholecystokinin and vasoactive intestinal polypeptide was observed by immunohistochemistry indicating increased neuronal peptide concentrations. These results were supported by radioimmunoassays showing increased ganglionic levels of substance P and vasoactive intestinal polypeptide. Both techniques, however, failed to show a significant increase of somatostatin levels.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ratas
/
Colecistoquinina
/
Péptido Intestinal Vasoactivo
/
Sustancia P
/
Hormonas Gastrointestinales
/
Animales Recién Nacidos
/
Factores de Crecimiento Nervioso
/
Neuronas Aferentes
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1982
Tipo del documento:
Article
Pais de publicación:
Irlanda