Relationship between snRNA species contained in nuclear antigens recognized by autoantibodies and the clinical profile in systemic rheumatic diseases.
Biomed Pharmacother
; 36(3): 134-9, 1982.
Article
en En
| MEDLINE
| ID: mdl-6185159
Antibodies to extractable nuclear antigens (ENA) are generally used in the diagnosis of connective tissue diseases. Using a rapid, very sensitive method we have shown that extractable nuclear antigens, which are now well-characterized at the molecular level, differ by their RNA content. The method was applied to the sera of 17 patients suffering from different connective tissue diseases. The results show that mixed connective tissue disease (MCTD) and other mild connective tissue diseases are characterized by the presence in the antigen of U1 small nuclear RNA (U1 snRNA) only. On the other hand, antibodies from 6 out of 8 patients tested with Systemic Lupus Erythematosus (SLE) recognize antigens exhibiting a more complex RNA pattern. Three of them precipitated all five snRNAs U2, U1, U4, U5, U6 whereas some snRNAs were lacking or quantitatively less important in precipitates obtained with the three others.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN
/
Anticuerpos Antinucleares
/
Enfermedades Reumáticas
/
Nucleoproteínas
Límite:
Humans
Idioma:
En
Revista:
Biomed Pharmacother
Año:
1982
Tipo del documento:
Article
Pais de publicación:
Francia