Tumor and histocompatibility antigen interaction: direct visualization by a double-label bridging technique for immuno-electron microscopy.
Mol Immunol
; 19(8): 973-82, 1982 Aug.
Article
en En
| MEDLINE
| ID: mdl-6182456
The nature of the interaction between the Ib tumor-associated surface antigen (Ib-TASA) and the Dk and Kk (Dk/Kk) regions of the major histocompatibility complex on the surface of line Ib lymphocytes was evaluated by immuno-electron microscopy using a double-label bridging technique. Quantitation of antigenic sites by direct counts showed 44% of the Ib-TASA sites coincident with Dk/Kk antigens. This is greater than the predicted random interaction of two independent cell surface determinants suggesting an associative interaction, i.e. 'altered-self' antigen. The remaining 56% of the Ib-TASA sites were in a non-associative mode. On the basis of data presented here, we postulate that the interaction between 'self'- and 'non-self' antigens is not an 'all or none' phenomenon.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Histocompatibilidad
/
Epítopos
/
Antígenos de Neoplasias
/
Antígenos de Superficie
Límite:
Animals
Idioma:
En
Revista:
Mol Immunol
Año:
1982
Tipo del documento:
Article
Pais de publicación:
Reino Unido