Interactions between primed and unprimed cells in the regulation of in vitro antibody responses. I. Role of "plasma cells" as inducers of suppression.
Eur J Immunol
; 12(1): 70-5, 1982 Jan.
Article
en En
| MEDLINE
| ID: mdl-6174349
Specific immune suppression has been shown to be activated in culture by the interaction of primed and unprimed T cell subsets. The primed cell involved is found 8 days after immunization in spleen but not in lymph node or thymus cell populations. When the primed spleen cells were fractionated by nylon wool passage or anti-Thy-1 plus complement (C) treatment, prior to culture with unseparated unprimed cells, suppression was detectable only with primed B cells present in the co-cultures. Treatment of the primed spleen cells with anti-PC.1 (an antiserum specific for plasma cells) plus C eliminated their ability to cooperate with either unseparated or T cell-enriched populations of unprimed cells in suppressing the antibody response of the co-cultures. These data are consistent with the hypothesis that antibody-secreting plasma cells activate suppressor T cell precursors in cell populations not previously exposed to antigen.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Plasmáticas
/
Linfocitos B
/
Linfocitos T
/
Cooperación Linfocítica
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
1982
Tipo del documento:
Article
Pais de publicación:
Alemania