Circulating autoantibodies to hidden mitochondrial antigenic determinants in mammals.
Ann Allergy
; 47(1): 1-4, 1981 Jul.
Article
en En
| MEDLINE
| ID: mdl-6167180
Autoantibodies to equine cytochrome c and to porcine malic dehydrogenase are shown in equine and porcine serum, respectively, by immunodiffusion. A confluence of arcs between human plasma and rabbit, horse and pig serum against these antigens suggests the presence of antibodies in human plasma to cytochrome c and malic dehydrogenase. The use of tris buffer containing a low concentration of Dodecyl sodium sulfate for cytochrome c and of glycerol for malic dehydrogenase maintains their solubility and enhances their participation in antibody-antigen immunoprecipitation possibly by unravelling the peptide chains and exposing reactive antigenic determinants hidden within the interstices of the cytochrome c and malic dehydrogenase molecules.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Circulación Sanguínea
/
Mitocondrias
/
Epítopos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Ann Allergy
Año:
1981
Tipo del documento:
Article
Pais de publicación:
Estados Unidos