Further studies on the xylazine-yohimbine interaction.
Pharmacol Res Commun
; 16(9): 865-74, 1984 Sep.
Article
en En
| MEDLINE
| ID: mdl-6095331
A study of the Yohimbine-blocking action upon Xylazine-ability to inhibit the abdominal contortions elicited by an intraperitoneal injection of Acetic Acid (60 mg/kg) was carried out. Xylazine (0.75 mg/kg - subcutaneously) inhibited 44% of the abdominal contortions. Such an inhibition activity was reduced to a 19% level after a previous Yohimbine treatment (1 mg/kg - intramuscularly - 30 min before). The results suggested there is a 2.9 times reduction of Xylazine affinity for CNS alpha 2 receptors, and that the antagonism between the two drugs is of a competitive nature.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiazinas
/
Xilazina
/
Yohimbina
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Res Commun
Año:
1984
Tipo del documento:
Article
Pais de publicación:
Estados Unidos