Effectiveness of cefotaxime in gram-negative meningitis.

LeFrock, J L; Molavi, A; Smith, B; Black, P; Rosenberg, M; Rolston, K; Brodner, R; Chandrasekar, P; Henao, L; Kannangara, D W

LeFrock, J L; Molavi, A; Smith, B; Black, P; Rosenberg, M; Rolston, K; Brodner, R; Chandrasekar, P; Henao, L; Kannangara, D W.

Neurosurgery ; 15(5): 679-82, 1984 Nov.

Article en En | MEDLINE | ID: mdl-6095133

RESUMEN

We treated 12 adult patients who had gram-negative bacillary meningitis with cefotaxime administered intravenously at a dose of 2 g every 4 hours. The etiological organisms included Haemophilus influenzae (3 cases), Serratia marcescens (3 cases), Klebsiella pneumoniae (3 cases), Escherichia coli (2 cases), and Enterobacter (1 case). The infection followed a neurosurgical procedure in 6 cases. The mean inhibitory and bactericidal concentrations of cefotaxime for the isolates ranged from 0.125 to 0.25 microgram/ml. The cerebrospinal fluid (CSF) concentrations of cefotaxime ranged from 5.0 to 15.2 micrograms/ml, and the CSF bactericidal titers were 1:64 to 1:128. The CSF in all patients was sterilized within 96 hours. All 12 patients recovered, and there were no relapses.

Asunto(s)

Infecciones Bacterianas/tratamiento farmacológico; Cefotaxima/uso terapéutico; Meningitis/tratamiento farmacológico; Adulto; Infecciones por Enterobacteriaceae/tratamiento farmacológico; Infecciones por Escherichia coli/tratamiento farmacológico; Humanos; Infecciones por Klebsiella/tratamiento farmacológico; Klebsiella pneumoniae; Meningitis por Haemophilus/tratamiento farmacológico; Persona de Mediana Edad; Serratia marcescens

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Cefotaxima / Meningitis Límite: Adult / Humans / Middle aged Idioma: En Revista: Neurosurgery Año: 1984 Tipo del documento: Article Pais de publicación: Estados Unidos

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