Cyclic nucleotides and calcium transport in cultured dermal fibroblasts from progressive systemic sclerosis and rheumatoid arthritis patients.

Grozdova, M D; Khokhlova, J V; Panasyuk, A F; Guseva, N G; Trofimova, T M

Grozdova, M D; Khokhlova, J V; Panasyuk, A F; Guseva, N G; Trofimova, T M.

Arthritis Rheum ; 27(10): 1144-9, 1984 Oct.

Article en En | MEDLINE | ID: mdl-6091700

RESUMEN

Levels of cAMP were decreased and cGMP increased in progressive systemic sclerosis (PSS) fibroblasts compared with normal fibroblasts. PSS cells took up unusually large quantities of Ca++. The epinephrine-induced increases in cAMP were diminished sixfold and epinephrine-induced Ca++ uptake was abnormal in PSS cells. Considerable heterogeneity was observed in rheumatoid arthritis fibroblasts. Membrane-bound abnormalities in (PSS) cells may be of importance in the defective control of collagen production in progressive systemic sclerosis.

Asunto(s)

Artritis Reumatoide/metabolismo; Calcio/metabolismo; AMP Cíclico/metabolismo; GMP Cíclico/metabolismo; Esclerodermia Sistémica/metabolismo; Piel/metabolismo; Adolescente; Adulto; Artritis Reumatoide/patología; Transporte Biológico/efectos de los fármacos; Células Cultivadas; Colágeno/biosíntesis; Epinefrina/farmacología; Femenino; Fibroblastos/metabolismo; Humanos; Masculino; Persona de Mediana Edad; Propranolol/farmacología; Esclerodermia Sistémica/patología; Piel/patología

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Esclerodermia Sistémica / Piel / Calcio / AMP Cíclico / GMP Cíclico Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Rheum Año: 1984 Tipo del documento: Article Pais de publicación: Estados Unidos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links