Studies on bleomycin-DNA and bleomycin-iron interactions.
J Biomol Struct Dyn
; 1(3): 809-27, 1983 Dec.
Article
en En
| MEDLINE
| ID: mdl-6086062
The bleomycins, a group of antitumor antibiotics (Figure 1), cause the degradation of DNA by a process requiring iron(II) and dioxygen (1,2). DNA degradation appears to involve two steps: association of the drug with the nucleic acid and degradation of the DNA. As part of studies directed toward achieving an understanding of how the bleomycins degrade DNA, we have examined various properties of the drug using a variety of chemical and physico-chemical techniques, including NMR and Mössbauer spectroscopy. We have studied both the interaction of the antibiotic with its target (DNA) as well as its association with its metal ion cofactor. This work has been performed on the intact drug and its derivatives as well as on synthetic models of the parent drug. This paper reviews and updates the recent work from this laboratory on the bleomycins.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bleomicina
/
ADN
Idioma:
En
Revista:
J Biomol Struct Dyn
Año:
1983
Tipo del documento:
Article
Pais de publicación:
Reino Unido