[FAB immunoglobulin fragments. I. The comparative characteristics of the serological and virus-neutralizing properties of a gamma globulin against tick-borne encephalitis and of the FAB fragments isolated from it]. / FAB-fragmenty immunoglobulinov. Soobshchenie I. Sravnitel'naia kharakteristika serologicheskikh i virusneitraliziruiushchikh svoistv gamma-globulina protiv kleshchevogo éntsefalita i vydelennykh iz nego FAB-fragmentov
Zh Mikrobiol Epidemiol Immunobiol
; (6): 51-7, 1976 Jun.
Article
en Ru
| MEDLINE
| ID: mdl-60019
A comparative study was made of the serological properties and virus-neutralizing activity of antiencephalitis gamma-globulin and Fab-fragments isolated from it by gel-filtration. Horse immunoglobulins against the autumno-summer tick-borne encephalitis virus could be disintegrated with the aid of papaine to monovalent Fab-fragments which (according to the complement fixation reaction, the test of suppression of the complement fixation, and the HAIT) retained the serological activity whose level was compared with that of the serological activity of gamma-globulin. Fab-fragments possessed a marked virus-neutralizing activity. The mean value of a logarithm of the neutralization index was 2.65 +/- 0.2 for Fab-fragments and 3.74 +/- 0.38 for gamma-globulin (P less than 0.01).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gammaglobulinas
/
Fragmentos Fab de Inmunoglobulinas
/
Encefalitis Transmitida por Garrapatas
Límite:
Animals
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Año:
1976
Tipo del documento:
Article
Pais de publicación:
Rusia