Biliary excretion of iodipamide and iodoxamate in dogs with hepatic dysfunction induced by oral administration of dimethylnitrosamine.
Invest Radiol
; 14(6): 502-7, 1979.
Article
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| MEDLINE
| ID: mdl-583337
Iodipamide and iodoxamate were compared in equimolar clinical dosages in five cholecystectomized chronic bile fistula dogs in which hepatic dysfunction was produced by oral administration of a total dose of 480 and 960 microliters dimethylnitrosamine (DMNA), respectively. After both DMNA dosages, the peak biliary excretion rate for iodoxamate was significantly higher than for iodipamide (p less than 0.01). The peak bile iodine concentration was not significantly different for the two agents (480 microliter DMNA: p less than 0.1; 960 microliter DMNA: p = 0.07). On the basis of this investigation, it is suggested that iodoxamate should not significantly improve the opacification of the biliary system in patients with hepatic dysfunction.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Triyodobenzoicos
/
Conductos Biliares
/
Dimetilnitrosamina
/
Yodipamida
/
Yodobenzoatos
/
Hepatopatías
Límite:
Animals
Idioma:
En
Revista:
Invest Radiol
Año:
1979
Tipo del documento:
Article
Pais de publicación:
Estados Unidos