The role of blood clotting factor V in the conversion of prothrombin and a decarboxy prothrombin into thrombin.
Biochim Biophys Acta
; 538(3): 521-33, 1978 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-564211
Purified PIVKA-II exhibits some factor II (prothrombin) activity in the one-stage coagulation assay and this factor II activity does not come from residual amounts of factor II but originates from PIVKA-II itself. It is shown that PIVKA-II is converted by a normal prothrombinase complex (factor Va and factor Xa adsorbed onto a phospholipid interface) more readily than by phospholipids and factor Xa alone. This suggests that binding between PIVKA-II and factor Va is an essential feature in the formation of the enzyme . substrate complex and from this we infer that a direct interaction between factor Va and prothrombin plays a rôle in the prothrombinase . prothrombin complex.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor V
/
Protrombina
/
Trombina
Límite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1978
Tipo del documento:
Article
Pais de publicación:
Países Bajos