Mitochondrial DNA synthesis in mouse L cells temperature sensitive in nuclear DNA replication.
Can J Biochem
; 55(5): 543-7, 1977 May.
Article
en En
| MEDLINE
| ID: mdl-560242
Temperature-sensitive (ts) A 1S9 mouse L cells continue to synthesize double-stranded covalently closed mitochondrial (mt) DNA at a temperature (38.5 degrees C) which is nonpermissive for chromosomal DNA replication. The amount of mt DNA made appears to be quantitatively linked to nuclear DNA synthesis. Nuclear DNA replication proceeds normally for 6-8 h after the cells are shifted to 38.5 degrees C, and then declines to reach a minimum at 20-24 h. The level of mt DNA synthesis remains high during this period and decreases once the ts lesion has been established.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN Mitocondrial
/
Células L
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Can J Biochem
Año:
1977
Tipo del documento:
Article
Pais de publicación:
Canadá