Interaction between anticoagulants and contraceptives: an unsuspected finding.
Br Med J
; 2(6200): 1260-1, 1979 Nov 17.
Article
en En
| MEDLINE
| ID: mdl-519402
ABSTRACT
PIP: Of 197 patients with heart disease on oral anticoagulant treatment (nicoumalone) 12 were simultaneously taking an estroprogestogenic oral contraceptive. The patients were aged 27-44 years old and anticoagulation control was maintained by measuring prothrombin activity. For 230 months the women took anticoagulant only. The mean prothrombin time ratio was significantly higher when the women were taking both the anticoagulant and the pill than taking only the anticoagulant, but the prothrombin values were in the therapeutic range during both periods. The oral contraceptive seems to potentiate anticoagulation activity not diminish their effect. It is suggested that the estrogen in the pill may produce enzymatic inhibition in microsomes of hepatic cells which potentiate anticoagulant activity through retarded metabolic degradation.
Palabras clave
Biology; Blood Coagulation Effects; Clinical Research; Contraception; Contraceptive Methods; Diseases; Endocrine System; Enzyme Inhibitors; Enzymes And Enzyme Inhibitors; Estrogens; Family Planning; Heart Diseases; Hematological Effects; Hemic System; Hormones; Oral Contraceptives; Oral Contraceptives, Combined; Physiology; Research Methodology
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anticonceptivos Orales
/
Acenocumarol
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Br Med J
Año:
1979
Tipo del documento:
Article
Pais de publicación:
Reino Unido