Effect of methadone and morphine on serotonin uptake in rat periaqueductal gray slices.
Eur J Pharmacol
; 59(1-2): 107-10, 1979 Oct 26.
Article
en En
| MEDLINE
| ID: mdl-510390
In vitro effects of d,l-methadone and morphine on [3H]serotonin (3H-5-HT) uptake in rat periaqueductal gray (PAG) slices were investigated. Only methadone had a significant inhibitory effect on 3H-5-HT uptake which was significantly enhanced by naloxone. The systemic administration of methadone did not affect 3H-5-HT uptake in vitro. These data further weaken the possible relationship between narcotic analgesia and blockade of the 5-HT reuptake mechanism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Serotonina
/
Metadona
/
Morfina
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
1979
Tipo del documento:
Article
Pais de publicación:
Países Bajos