Metabolic changes in red blood cells in malignant lymphomas.
Br J Haematol
; 42(1): 35-9, 1979 May.
Article
en En
| MEDLINE
| ID: mdl-465359
Serum copper levels (SCL) which are concomitantly related to red blood cell free copper are significantly increased in some malignant lymphomas in the phase of activity. This results in a profound inhibition of red cell key glycolytic enzymes, hexokinase (Hx) being the most sensitive. Fifteen patients (eight with Hodgkin's disease and seven with non-Hodgkin's lymphoma) were studied for serum and red cell copper concentrations and Hx activity. The mean red cell life span was determined using 51Cr labelled red cells. The resulting data shows that in active disease an increase in SCL was associated with a decrease in Hx activity and a shortened red cell survival. In these cases there was no evidence of autoimmune phenomena or of direct bone marrow involvement by the disease. It is suggested that the increase in copper levels results in a shortened red cell life span through a copper-induced inhibition of red cell Hx.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cobre
/
Eritrocitos
/
Hexoquinasa
/
Linfoma
Límite:
Humans
Idioma:
En
Revista:
Br J Haematol
Año:
1979
Tipo del documento:
Article
Pais de publicación:
Reino Unido