Effects of carbenicillin on blood coagulation: a study in patients with chronic renal failure.

Tabernero Romo, J M; Corbacho, L; Sánchez, S; Rodríguez, J L; Macías, J F; del Cañizo, C; de Castro, S

Tabernero Romo, J M; Corbacho, L; Sánchez, S; Rodríguez, J L; Macías, J F; del Cañizo, C; de Castro, S.

Clin Nephrol ; 11(1): 31-4, 1979 Jan.

Article en En | MEDLINE | ID: mdl-428153

RESUMEN

A study of coagulation has been performed on 8 chronic renal failure patients receiving carbenicillin therapy. All showed a prolongation of the bleeding, recalcification, partially-activated thromboplastin, prothrombin and thrombin times. These findings suggest the presence of an anticoagulant with an heparin-like mode of action. In vitro tests suggest that carbenicillin may be this factor. We have also shown that the drug produces a disturbance in the normal polymerization process. The implications of these findings for the treatment of (CRF) patients with carbenicillin are discussed.

Asunto(s)

Coagulación Sanguínea/efectos de los fármacos; Carbenicilina/farmacología; Fallo Renal Crónico/sangre; Pruebas de Coagulación Sanguínea; Carbenicilina/administración & dosificación; Humanos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Coagulación Sanguínea / Carbenicilina / Fallo Renal Crónico Límite: Humans Idioma: En Revista: Clin Nephrol Año: 1979 Tipo del documento: Article Pais de publicación: Alemania

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