Inhibition of platelet aggregation by a new agent, Ticlopidine.
Thromb Haemost
; 40(3): 542-50, 1979 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-425067
Effect of Ticlopidine, 5-(2-chlorobenzyl)-4, 5, 6, 7-tetrahydro[3,2-C]pyridine hydro-chloride, on platelet aggregation was studied in the rat. Ticlopidine was found to be a potent, long-lasting inhibitor of platelet aggregation. It inhibited the aggregation induced by any of ADP, collagen, thrombin, arachidonic acid and prostaglandin endoperoxides and/or thromboxane A2-like substancee. Ticlopidine was effective at doses as low as 30 mg/kg when orally given to rats, and the effect lasted as long as the life span of the circulating platelets (half time: about 48 hours). Ticlopidine inhibited also nucleotide release from and prostaglandin synthesis in the platelets, but did not significantly affect platelet adhesiveness to glass, platelet factor 3 availability and clot retraction.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridinas
/
Tiofenos
/
Agregación Plaquetaria
Límite:
Animals
Idioma:
En
Revista:
Thromb Haemost
Año:
1979
Tipo del documento:
Article
Pais de publicación:
Alemania